WordPress Blog

Welcome to the Rosacea Diet Users Support Group
You may begin posting emails to the Group and need some
questions answered, so here are some answers:
Rosacea Diet Users Support Group FAQs

i have controlled it by one taking medication, i
believe tectrcycline, also using metrol gel BUT the
major one is stop eating sugar!!! stopped putting hot
water on my face, Donot put bezoal peroxide because
that will make it worse. and take some vitamin e and
A!
Stop eating sugar!

Does anyone have any tips about how to control ocular rosacea? Thank you.
Eileen

Occular rosacea is a distressing malady. First, are you seeing a
dermatologist and if so, have you purchased Nase's book? He
discusses occular rosacea when being treated by a physician
and is a must have if you are. His book is listed in the BOOKS
section on my site. Here is a link I have listed on my LINKS
page for occular rosacea:
http://www.chcp.com/messages/433.html
hope this helps. And maybe someone else will give you some
help too.
Brady Barrows
--- In rosacea-diet-users-support-group@y..., "Eileen Kast"

Welcome to the Rosacea Diet © Users Support Group.....
you may post anything you wish for the group to respond to and I
will add anything I may help with as the moderator.....
Brady Barrows, Author of the Rosacea Diet ©
http://www.rosaceadiet.com

The Noxadem User Database has posted five comments:
http://rosaceans.com/html/noxademdatabase.html
NO: 3
YES: 2
I have pointed out to the Noxadem company that some are
reporting stinging and burning when applying the Noxadem.
The company is listening to these results since they want
feedback and we are doing just that. Greg McCullough, Noxadem
spokesman, says that the company will be coming out with
a new forumla that should reduce the stinging/burning and
will notify me when samples are available.
If anyone wants to try the Noxadem sample available now
please email me with your name and address and a free
sample of Noxadem will be shipped to you in 2 to 4 weeks.
webmaster@...

Hello everyone,
My name is Kris. I decided to post here as I would like to share my
experiences with Roscea. I have had some horrible painfull out breaks
which have left scars on my face.
However after using the Doxycyline to get rid of the out breaks I
then started applying make up and am amazed at the results! My skin
has not had one single out break in over a month! Even my husbands
has noticed and made comments about how good my skin looks. I have
also not been taking my daily dose of anti-biotics, and still, no out
breaks as long as I protect my skin with make up. Sun screen also
works.
Rocea ointments are *very* expensive! After much observation I would
have to guess that once the inflamation is gone, simple measures of
using either sunscreen or make-up to protect the skin can make all of
the difference in the world, not to mention the pocket book.
Have a Blessed Holiday Season,
Kris (o:

Another rosacea variant has been identified, Gnatophyma, which
is added to the list of variants at this url
http://www.rosaceans.com/html/confusion.html
Brady
group owner
Source
Gnatophyma: A rare rosacea phyma variant
Journal of the American Academy of Dermatology, Volume 55, Issue 1,
July 2006, Pages 165-166
Erum N. Ilyas, Matthew R. Hanson, Naomi Lawrence and Justin J. Green
Article found at
http://www.sciencedirect.com/science?
_ob=ArticleURL&_udi=B6WM8-4K662KF-1K&_user=10&_coverDate=07%2F31%
2F2006&_alid=513703481&_rdoc=4&_fmt=summary&_orig=search&_cdi=6928&_sort=d
&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md
5=4eba99433be756bd3c6e07ad99438422

Kris,
Are you using a specific makeup?
Thanks,
Cathy

No I am not using anything specific. I tend to buy the most
affordable make-up and that is all. Along with good skin lotion, I
use a combination of foundation and cover-ups. My experience has been
that once the inflamation is under control through a temporary
regimen of anti-biotics all I have to do is cover my entire face with
sun screen and/or make-up and I'm home free with very few if any
flare ups.
I often times get them if I get angry at someone or I'm stressed
about something there has been a drastic change in the weather.
However the areas where the skin is protected rarely have an out
break.
Through constant use of skin cover ups I haven't had to touch my oral
medication for almost a month now!
Seasons Blessings,
Kris (o:

It has been generally understood that "demodicoses are thought
to be rare, occurring mainly for patients with immunosuppression."
A study released in January 2005 had the objective "to demonstrate
the high frequency of demodicoses and the overlapping with
papulopustular rosacea (PPR) ." What did the study reveal?
"RESULTS: In all, 4372 diagnoses, in which 115 were demodicoses,
were collected among 3213 patients. Demodicosis was the 9th most
frequent diagnosis (13th new). Each dermatologist observed an average
of 2.4 demodicoses a week (1.2 new). The proportion of demodicoses
varied greatly according to the dermatologist. The general status was
good in 110 patients; only 3 had known immunodeficiency. The most
frequent symptoms were follicular scales (71%) and telangiectasia (63%).
The mean Dd was higher in pityriasis folliculorum (m = 61 D/cm 2 ) than
in PPR (m = 36 D/cm 2 ; P = .04); 42 patients with PPR had a high Dd,
6 had a low Dd. CONCLUSION: Demodicoses are frequent and occur
among patients who are immunocompetent. PPR with normal Dd are rare."
Journal of the American Academy of Dermatology
source of study can be found at this url
http://www.rosaceans.com/html/demodex.html

Good basic skincare can also make a big difference for many people. But so many
are afraid to use anything new on their skin.
Please share with us exactly what you are using.
I have been using a professional line of skincare and Jane Iredale mineral
makeup, it covers the red and helps it heal as well.
Doxycycline also helped my outbreak clear up but I am not going to take it
longterm due to the side effects of long term antibiotics.
Noreen

I use cory cosmetics mineral makeup and that seems to help a lot.
Maureen
home16paws <home16paws@...
Good basic skincare can also make a big difference for many people. But so many
are afraid to use anything new on their skin.
Please share with us exactly what you are using.
I have been using a professional line of skincare and Jane Iredale mineral
makeup, it covers the red and helps it heal as well.
Doxycycline also helped my outbreak clear up but I am not going to take it
longterm due to the side effects of long term antibiotics.
Noreen

Nikki,
there are many mineral makeups that will cover the red and be good for your
skin at the same time.
I really Like Jane Iredale mineral makeup, and it comes in sample sizes so you
can try it before buying a large size.
Go to their website and see who sells it near you, usually doctors and
estheticians, have them apply it for you so you can see what color works and how
you like it.
Illuminare is another one, liquid mineral foundation.
Noreen

Has anyone tried the Cutanix products for rosacea?
If so, I would appreciate you posting not only here but
also in the new Cutanix database I have created for
user comments at this url
http://www.rosaceans.com/html/cutanixdatabase.html
I have a list of databases for your viewing at this url
http://www.rosaceans.com/html/databases.html
thanks,
Brady
group owner

Has anyone heard of Neova R2 or tried it?
http://www.rosaceans.com/html/neova.html
Brady
group owner

This product sounds of interest. It contains Hesperiden, which is excellent for
allergies.
I'd love to know if anyone has used it and the results they got.
There are so many products out there now claiming to be good for rosacea, just
making it more confusing for the sufferer.
Noreen

Donations made to the Rosacea Research & Development Institute since January
13, 2006 are tax deductible. If you need a receipt for tax purposes, send
me an email with RRDi in the subject line.
I do want to thank all who have made monetary donations. I also want to
take this opportunity to thank all who donated their time and talents.
Volunteerism drives the RRDi.
2007 gives us all a new opportunity to help at the RRDi. Stop by and see
how we can put you to work!
Cathy L. Rupert
Treasurer
Rosacea Research and Development Institute
RRDi
http://irosacea.org/

A new product from Woodridge Labs., Inc. of Van Nuys, CA
called, Virtual Laser Redness Rescue, which according to
advertisment contains "a revolutionary, Neurocosmetic®
patented ingredient designed to reduce the visible signs
of minor irritation. This action immediately calms and soothes
the skin, helping to prevent further symptoms of irritation.
The result: natural, even toned skin that feels soft and smooth."
For more information and a list of the ingredients go to
http://www.rosaceans.com/html/vlrr.html
We shall no doubt hear about this new rosacea product
from users whether this helps or not.
Brady
group owner

Hello everyone
I was away on holiday in Arizona and I stumbled across Virtual Laser Redness
Rescue in Walgreens.
I purchased one on the condition that I was able to return it if it burned or
cause me more grief. She said I would be able to so I bought it. It was around
$25 as I recall.
It did not burn me or cause any problems, and I think it did help ( my husband
thought it reduced redness). I bought another before we left.
Sorry that I can't say anything more definite, but my skin tolerating it is a
big positive step for me!
Happy New year to all
regards,
Aimee
Brady Barrows <brady@...
A new product from Woodridge Labs., Inc. of Van Nuys, CA
called, Virtual Laser Redness Rescue, which according to
advertisment contains "a revolutionary, Neurocosmetic®
patented ingredient designed to reduce the visible signs
of minor irritation. This action immediately calms and soothes
the skin, helping to prevent further symptoms of irritation.
The result: natural, even toned skin that feels soft and smooth."
For more information and a list of the ingredients go to
http://www.rosaceans.com/html/vlrr.html
We shall no doubt hear about this new rosacea product
from users whether this helps or not.
Brady
group owner
PLEASE DO NOT send a message to the group to
unsubscribe or change your email settings for the
group.
to temporarily suspend email go to this url

It ceases to amaze me how many new rosacea products are on
the market now:
Here is a partial list:
Neova R2 Virtual Laser Redness Rescue
Kerstin Florian Rosacea Hyaluronic Serum
HealioHealth Rosacea Treatment Benev Azalex
Flexelle Suki Love at First Touch Rosacea Skin Care Kit
Pritika Ole Henriksen
You may learn more about these products at this url
http://www.rosaceans.com/html/news.html
Brady
group owner

Found some more rosacea products (this list keeps growing):
Rodan and Fields Unblemish Regimen
http://www.rosaceans.com/html/rodanfields.html
Donell Super Skin Rosacea Therapy and (Super Skin) K-Derm Gel
http://www.rosaceans.com/html/donell.html
Celazome Serum Vitae
http://www.rosaceans.com/html/celazome.html
This is going to be a banner year for new rosacea products.
Brady

Seems everyone is jumping on the rosacea bandwagon but many don't have very good
products.
Many of the ingredients in the Rodan and Fields concerns me.
I prefer some of the professional products, which put a bit more research into
what goes into their products.
Noreen

Another rosacea product by SeSDerma Laboratories
http://www.rosaceans.com/html/azelac.html
Brady
Group Owner

Dear Brady.
Just read that azeloglcine which i guess is the key ingredient of this new
product is a skin lightening agent. Could this cause more damage then good? As a
rosy cheeks as i call myself, i have tried the whole lot but always go back to
the jojoba oil, cheap and simple.
best wishes Barbara.
Brady Barrows <brady@...
Another rosacea product by SeSDerma Laboratories
http://www.rosaceans.com/html/azelac.html
Brady
Group Owner

I haven't heard anything about azeloglcine or any
of the new rosacea products' ingredients or whether
they work or not. No doubt rosaceans will report
what results they are getting with these no products
but it takes time to get feedback. My recommended
regimen can be found at this url
http://www.rosaceans.com/html/z6.html
Brady
group owner

Welcome to the group Denise.
Hormones could be playing a big part. My rosacea has worsened since I have been
perimenopausal.
Stress definitely flares mine up.
Recently mine was migrating to the forehead or something else was going on with
the forehead. An esthetician I know insisted that I get on a good skincare
regime and started using PCA products.
This system has worked well for me. The trick is to find skincare products that
agree with your skin, as we all know, that can take years of trying.
I had a thought, with Fibromyalgia and CFS you are already experiencing immune
problems. The prednisone may not be helping in the long run OR the antibiotics.
There's a new low dose doxycycline on the market, not cheap of course, but it
has been approved for rosacea.
With Fibromyalgia and CFS there is often food allergies, you should consider
that and perhaps see a good naturopathic doctor to help you find out what they
are.
Sugar and caffeine doesn't help. Perhaps starting by eliminating those first.
I have considered laser or IPL but I'm waiting to hear more positive feedback on
both.
Noreen

Another rosacea product on the market
http://rosacea-control.com/html/ddf.html
New ones seems to be marketed on a daily basis and
it it getting to be a crowded market.
All these new rosacea products should be tested by
an independent non profit organization like the
RRDi. Maybe someday all this can be accomplished
to be able to sort out the good from the bad. For
now all we can do is look at the ingredients and
read anecdotal reports on the internet.
If you want to join the RRDi go to this url
http://www.irosacea.org
Brady
group owner

Are there links for alternative care and treatment that are non-commercial?
So far much of what I seem to be reading seems to be from people marketing
their own products. I tend to be concerned about the objectivity and bias
in such links.
Denise

Denise,
I have founded the Rosacea Research & Development Institute which
is an approved 501 (c) (3) approved non profit organization at this
url
http://www.irosacea.org
Everyone in the above organization are volunteers and you can come
join and help make the RRDi a better organization. I have spent my
own money to form this organization initially and spent countless
volunteer hours making it grow to what you can read about above. I
can use more volunteers.
I have a commericlal web site for rosacea that is a commercial clearinghouse
of information for the control of rosacea which is the sister site for this

It seems to check out as legitimate--the company conducting the study is based
in
northern New Jersey. Here's the link:
http://www.tklresearch.com/index.htm
I'm assuming it is a U.S. based study.
Pam in DC
(as moderator)

NOTICE:
We are searching for adults 18 years and older with acne-rosacea - both
persistent redness and at least 10 acne-like bumps on their faces - to
participate in a nationwide research study to treat this more advanced
rosacea condition.
Qualified adults will receive study medication and reimbursement for
time and travel.
To find out if there is a study location near you, please send an email
to: rosaceastudy@.... Please include: your age, city and
state. We will return your email within 24 hours with the clinical
study location nearest you.

Has anyone else tried it? I have been following the diet pretty close
and added acvwm. My redness has completely gone from my ears and neck
and upper chest and almost from my face. Also the bumps, pustules, and
papules have receded. I use about a tbsp in a cup of water about 3
times a day and also dillute it and use it for a toner on a cotton
ball.

Hi. I was wondering how much water and how much of the apple cider vinegar
you use. Thanks!
Charlotte
_____

I started out using about 1/3 acvwm to 2/3 distilled water, so just
a small amount in a dish and apply with a cotton ball. I have worked
up to full strength in about 2 weeks time. I always use fresh so it
doesn't go bad. Don't know if it would i'd just rather not chance
it. Then I apply aloe vera gel and a lotion made by Paula's Choice,
skin recovery moisturizer(its the only lotion I have personally
found that does not irritate my skin and I feel I've tried them
all). When I drink the acvwm I use about a Tbsp in a glass of water
2-3 times a day. After doing much research on this it seems that it
aids in digestion. I may have a deficiency in hydrochloric acid. But
two things I know for sure, my skin probs are directly related to
eating and the other is that the acvwm and better eating habits have
excellent clearing effects of my skin. Hope this helps someone.

Is anyone going to participate in this. Wish I could. Sure do have the redness
but not enough bumps to qualify.
Noreen

The Rosacea Research & Development Institute [RRDi] is pleased
to announce that Joel T. Bamford, M.D., SMDC Health System,
Duluth, MN, USA, has been appointed as a member of the
Medical Advisory Committee for the RRDi.
Dr. Bamford has served as a former member of the FDA Medical
Advisory Board in Dermatology. He currently serves as a
Reviewer for the Standard Classificatioon Evaluation for the NRS
and as a Reviewer for Cochrane Review of Rosacea Treatments.
His PubMed articles he has written can be reviewed below:
http://tinyurl.com/2mdopq
The RRDi is pleased that Dr. Bamford has agreed to volunteer
his time to assist the RRDi.
The RRDi is a 501 (c) (3) approved non profit organization that has
been built entirely by volunteer rosaceans. The MAC members are
all professionals who are volunteering their time to listen to the
concerns of rosacea sufferers in a safe private forum for corporate
members. Corporate members are required to give their identity and
mailing address before being approved to be able to access our private
forum. The RRDi has a strict privacy policy and your privacy is safeguarded.
The RRDi has professional grant writers who have volunteered to write
grants on rosacea research who will be later compensated 10% of whatever
money brought to the RRDi for this purpose. Amateur grant writers are
encouraged to volunteer as well and learn from the professionals how to
write grants in the private forum section for grant writers. If you wish to
learn more about this join the RRDi and volunteer as a grant writer.
Volunteering is the spirit behind the success of the RRDi and we encourage
you to bring what talents you have and any energy or time you would like to
give to find a cure for rosacea. If you would like to join please do so at this
url
http://members.irosacea.org/index.php?act=Reg&CODE=00
Finding the Cure - RRDi
Brady Barrows
Director RRDi
http://www.irosacea.org

Just wanted to introduce myself. I am a 33 yr old SAHM who was diagnosed about
9 yrs ago but had been having problems for YEARS. Dr told me what was wrong
with me when our daughter was sick. I have mainly used Metrogel as a RX med.
I have used every make up under the sun with nothing working to cover it and
most everything made it worse. Until Jan of last year when my dermatologist's
nurse told me about Physician's Formula. She swore by it and said it was
created by a dermatologist whose wife had rosacea. I tried it expecting the
worst. I was AMAZED. It hid my redness, and I didn't have problems the next
day with my face being horribly red. I have even had to reapply my make up for
evening wear and NOTHING the next day. My hubby says I have worn more make up
in the past 6-8 months than in the entire 11 yrs of our marriage. I have been
surprised by the fact if I just use the concealer and the powder, my redness is
still covered. I have been able to wear my
favorite color again- RED and it wasn't on my face!!! I can't say enough good
things about this make up. I'm always looking for ways to help with my rosacea
and how others deal with theirs.
Tonya

Thanks for the tip Tonya.
I really like Jane Iredale mineral makeup.
Many really like Illuminare which is a liquid mineral makeup.
Just want to throw out some more suggestions since we all respond differently to
different products.
Noreen

Tonya,
What Physician's Formula product(s) are you talking about?
Brady

Noreen,
PF has recently came out with the mineral make up. Wal-mart's policy is if
you try it and don't like it, bring it back with your receipt for a full refund.
I hadn't tried anything other than what I used as a teen because everything made
it worse when I could get it to cover so I have been just amazed by PF products.
Since I'm on disability, the fact they run $6-12 an item is something I can
afford. Right now their web site has "Try-it-free" rebate forms. Just thought
someone might like to know.
Thanks Tonya

All of their make up.
Tonya

I'm glad the PF is working for you Tonya.
Like many of the cosmetics in the drug stores, this line doesn't have the
greatest ingredients but what the heck, if it works and doesn't flare up your
rosacea, it's worth much more than what you paid for it.
I'll have to take a closer look next time I'm in the store.
Noreen

Jennifer
Hello and welcome to the group I have had rosacea for about 9 years. The
only makeup I have found that works for me is Physician's Formula. It covers
the redness and doesn't make it worse. Wal-mart and Meijer's has a satisfaction
guarantee on it. Try it if doesn't work take it back with your receipt and get
your money back.
My triggers are heat and cold crying stress coffee hot cocoa chlorine most
anything it appears. I use metrogel RX and that seems to help. Let me know
what works for you, please
Hugs and welcome Tonya

Hi Jennifer -
A few things that worked for me with favourable results :
* Water - and load of it.
* Antihistamine tablets (Cetirizine i think)
* Beta Blockers -- 2x40mg twice a day -- these helped with very positive
results with the whole stress aspect of flushing.... also to help with the
anxiety of flushing -- sometimes worrying about flushing is a trigger...
Quite interested to hear that you were diagnosed with flushing rosacea.... The
doctors/derms I have seen have been quite adament that rosacea and flushing are
not linked... Are there any papers on flushing rosacea i could read?
Have a good day,
M.
jregnault <jregnault@...

Welcome Jennifer.
I LOVE Jane Iredale mineral makeup. It's very clean and works wonderfully, no
junky ingredients in this product but it is expensive.
Laser, haven't had it done but am considering it, very expensive and no
guarantees. BE CAREFUL, you want this done by someone who has had a lot of
experience.
Stress is a big trigger for me too.
If you are dry you should be cleansing and moisturizing twice per day. Try
applying the moisturizer to a damp face.
I have had good luck with Dermalogica and PCA products, I didn't care for the
products you are using but we are all different and tolerate different things.
Welcome to the board.
Noreen

I am interested in the Physican's Formula coupon that is $1.00 off. If you have
it and won't use it please contact me.
Thanks Tonya

The Rosacea Research & Development Institute [RRDi] is pleased
to announce that Raymond Peat, Ph.Dl,, has been appointed as a member of the
Medical Advisory Committee for the RRDi.
Dr. Peat is a researcher and nutritional counselor and you can learn
about his background at this url
http://raypeat.com/
Dr. Peat has been interested in rosacea for about 40 years and wrote
an article entitled, "Rosacea, Rhinophyma, Pterygium & Riboflavin --
and Varicose Veins" in Townsend letter #49, p. 196 and other articles
about rosacea and related subjects.
The RRDi is pleased that Dr. Peat has agreed to volunteer
his time to assist the RRDi. He is joining 19 other professionals on
the RRDi Medical Advisory Committee [MAC] which you can review
at this url
http://irosacea.org/mac.php
The RRDi is a 501 (c) (3) approved non profit organization that has
been built entirely by volunteer rosaceans. The MAC members are
all professionals who are volunteering their time to listen to the
concerns of rosacea sufferers in a safe private forum for corporate
members. Corporate members are required to give their identity and
mailing address before being approved to be able to access our private
forum. The RRDi has a strict privacy policy and your privacy is safeguarded.
The RRDi has professional grant writers who have volunteered to write
grants on rosacea research who will be later compensated 10% of whatever
money brought to the RRDi for this purpose. Amateur grant writers are
encouraged to volunteer as well and learn from the professionals how to
write grants in the private forum section for grant writers. If you wish to
learn more about this join the RRDi and volunteer as a grant writer.
The board of directors of the RRDi are all suffering from rosacea and
this should encourage rosaceans that the RRDi will make decisions
regarding the spending of donations on rosacea research rather than the majority
of the funds being used for other purposes. You may review who is
volunteering on the board at this url
http://www.irosacea.org/board.php
Volunteering is the spirit behind the success of the RRDi and we encourage
you to bring what talents you have and any energy or time you would like to
give to find a cure for rosacea. If you would like to join please do so at this
url
http://members.irosacea.org/index.php?act=Reg&CODE=00
Finding the Cure - RRDi
Brady Barrows
Director RRDi
http://www.irosacea.org

ANyone using LTD III or a prescription sulphur topical for their
rosacea?
What results are you seeing?
thanks
Noreen

The board of directors has decided to allow the Ask the MAC section of
our private forum to go public. Warren, one of our webmasters, has finally
figured out how to do this magical feat which I tried to figure out for a
couple of hours and went bananas when it wouldn't do what I wanted it to
do. Thanks Warren. For those of you who would like to read what is happening
in the RRDi Ask the MAC here is the url
http://members.irosacea.org
We are still a long way from doing any actual research, but at least we have
the 'super forum' to ask some professionals who know rosacea some tough
questions and when they have the volunteer time, they will reply to our forum
members. If you want to join us, the RRDi requires no donation, nor does it
require you to volunteer your time. You can simply be a member and watch
what happens. It may be years down the road, but the RRDi is the only approved
non profit that is listening to rosaceans and has gathered some incredible
professionals into a forum for rosacea research. No other non profit
organization is like the RRDi, which has been made entirely by volunteer
rosaceans.
Brady Barrows
RRDi Director

Initially, I did see results. I actually have realized two areas of
redness. the area that got me talking to a doctor was the apples of my
cheeks. I'd wake up with them red unless I'd either slept 8+ hours or
laid in bed that long. The LTDIII took care of that. At least that was
an initial assumption. Sometimes I think it was just switching to
using Cetaphil and abandoning using Mary Kay timewise cleaning
products. The other area of redness is the rest of the side of my
face. I've not seen a great deal of improvement from the LTDIII alone.
At this point, I am using the Noxadem in the morning under makeup,
washing with Cetaphil per the LTDIII instructions and putting jojoba
oil on my face at night. Sometimes I use the LTDIII yellow sometimes I
do not. I have been considering ordering something else recommended to
the group. I do believe the Noxadem has helped in me not seeing a
couple of blood vessels so prominently on that side of my face.

Dr. Peat has responded to Mike's question below on r-s and I thought it would be
good to
also post this here FYI:
To: Brady Barrows <director@...
Subject: Re: post at rosacea support about an article you wrote
Yes, I'd be glad to answer his questions about the polyunsaturated fats.
Although that article, "Infant eyes, aging eyes, and excitable tissues," wasn't
about
rosacea, several of the studies it cited discuss the toxicity of the
polyunsaturated fatty
acids to the mitochondria, and since I think defects in mitochondrial
respiration cause
rosacea, they would be relevant. Besides directly inhibiting mitochondrial
respiration by
interacting with enzymes such as cytochrome oxidase, they have several indirect
effects
that work in the same direction, for example, the number of double bonds in
fatty acids
corresponds to their ability to inhibit the functions of the thyroid hormone,
and thyroid
function powerfully regulates mitochondrial respiration, especially the
cytochrome
oxidase.When fish oil or linseed oil is used as varnish, sunlight accelerates
the hardening
process by cross-linking the oil molecules. In living cells, the presence of
light-activated
catalysts, such as heme, riboflavin, tryptophan, and folic acid, and the metals
such as iron
that interact with them, increases the susceptibility of the unsaturated fats to
oxidation.
The highly unsaturated fatty acids produce some characteristic toxins, including
acrolein
and the isoprostanes, when they break down.
Exp Eye Res. 1995 Mar;60(3):307-16. Effect of dietary fat on the response of the
rat retina
to chronic and acutelight stress. Koutz CA, Wiegand RD, Rapp LM, Anderson RE.
Cullen Eye
Institute, Baylor College of Medicine, Houston, TX 77030, USA. We designed an
experiment
to study the role of light history and polyunsaturated fatty acids (PUFA) on the
susceptibility of the albino rat retina to light damage. Albino rats were born
to dams that
had been kept in either 1 lx or 250 lx cyclic light for 0-4 days prior to
delivery and fed one
of three diets containing either 10% (by weight) hydrogenated coconut oil (COC,
no n-3
nor n-6 fatty acids), safflower oil (SAF, high n-6, < 0.1% n-3 fatty acids), or
linseed oil
(LIN, high n-3, low n-6 fatty acids). After weaning, the rats were maintained in
the same
light environment and fed the same diets for 9 weeks, at which time some were
killed and
their retinas processed for morphometric analysis. Animals raised in bright
cyclic light had
shorter ROS lengths and thinner outer nuclear layers (ONL) than rats raised in
dim cyclic
light. The LIN animals had a thinner ONL than animals of the SAF or COC groups.
Rats
from each diet and light rearing groups were exposed to constant illumination of
2000 lx
for 24 hr, after which they and non-exposed controls were placed in 1 lx cyclic
light for 10
days and analysed for changes in ONL thickness. In the 250 lx (bright; B)
groups, there
was no effect of acute light stress on ONL thickness, although both control and
stressed
LIN animals had a thinner ONL than the corresponding COC and SAF groups.
However, in
the rats raised in 1 lx cyclic light, acute stress resulted in significant
retinal damage (i.e.
decrease in ONL thickness) in the three diet groups combined. The superior
region was
damaged the most and the severity was dependent on diet, as evidenced by the LIN
group
having a greater reduction in ONL thickness than the SAF group after light
stress. From
these results we conclude that rats on diets high in n-3 fatty acids are more
susceptible to
photoreceptor cell loss than animals fed n-6 or no polyunsaturated fatty acids
when raised
in dim cyclic light. These results show that both diet and light history play a
role in the
susceptibility of the retina to acute and chronic effects of light and suggest a
role for lipid
peroxidation in retinal light damage.
Prog Clin Biol Res 1989;312:95-112. The metabolism of omega-3 polyunsaturated
fatty
acids in the eye: the possible role of docosahexaenoic acid and docosanoids in
retinal
physiology and ocular pathology. Bazan NG.
J Neurochem 1988 Apr;50(4):1185-93. Induction of intracellular superoxide
radical
formation by arachidonic acid and by polyunsaturated fatty acids in primary
astrocytic
cultures. Chan PH, Chen SF, Yu AC.
Graefes Arch Clin Exp Ophthalmol 1993 Jul;231(7):416-23. Inhibition of
cytochrome
oxidase and blue-light damage in rat retina. Chen E. St. Erik's Eye Hospital,
Karolinska
Institute, Stockholm, Sweden. The activity of cytochrome oxidase, outer nuclear
layer
thickness, and edema were quantitatively evaluated in the blue-light exposed rat
retina.
Dark-adapted or cyclic-light reared rats were exposed to blue light with a
retinal dose of
380 kJ/m2. Immediately, 1, 2, and 3 day(s) after exposure, the retinas of six
rats from
each adaptation group were examined. There was no difference between the
dark-adapted
and cyclic-light reared rats. Immediately after light exposure, cytochrome
oxidase activity
decreased. The activity in the inner segments remained low at day 1, while
severe edema
was observed in the inner and outer segments. The outer nuclear layer thickness
decreased 1-3 days after exposure. The blue-light exposure inhibited cytochrome
oxidase
activity and caused retinal injury. Similarity of the injury process in the
dark-adapted and
cyclic-light reared retinas suggests that rhodopsin was not involved. The
inhibition of
cytochrome oxidase could be a cause of retinal damage.
Acta Ophthalmol Suppl 1993;(208):1-50. Inhibition of enzymes by short-wave
optical
radiation and its effect on the retina. Chen E. Eye Laboratory, St. Erik's Eye
Hospital,
Stockholm, Sweden. "Exposure to short-wave optical radiation is a potential
hazard for
vision. In the present study, blue-light damage is studied in rat retina." "Blue
light
inhibited cytochrome oxidase at a retinal dose of about 110 kJ/m2. This
inhibition was
reversible, and is probably related to the light regulation of retinal
metabolism. At a retinal
dose of about 380 kJ/m2, the inhibition of cytochrome oxidase was followed
consecutively
by a probable redistribution of chlorine and potassium in the inner and outer
segments,
damage to the mitochondria in the inner segments, edema in the inner and outer
segments, and progressive degeneration of photoreceptor cells. Dark adaptation
did not
increase the blue-light retinal injury. These findings support the hypothesis
that inhibition
of cytochrome oxidase is one of the causes of blue-light retinal damage."
J Neurosci Res 1988;19(1):94-100. Effects of arachidonic acid on respiratory
activities in
isolated brain mitochondria. Hillered L, Chan PH.
J Neurosci Res 1988 Aug;20(4):451-6. Role of arachidonic acid and other free
fatty acids
in mitochondrial dysfunction in brain ischemia. Hillered L, Chan PH.
J Neurosci Res 1989 Oct;24(2):247-50. Brain mitochondrial swelling induced by
arachidonic acid and other long chain free fatty acids. Hillered L, Chan PH.
Invest Ophthalmol Vis Sci 1996 Oct;37(11):2243-57. Retinal light damage in rats
with
altered levels of rod outer segment docosahexaenoate. Organisciak DT, Darrow RM,
Jiang
YL, Blanks JC. PURPOSE: To compare retinal light damage in rats with either
normal or
reduced levels of rod outer segment (ROS) docosahexaenoic acid. METHODS:
Weanling
male albino rats were maintained in a weak cyclic light environment and fed
either a
nonpurified control diet or a purified diet deficient in the linolenic acid
precursor of
docosahexaenoic acid (DHA). Half the rats on the deficient diet were given
linseed oil,
containing more than 50 mol% linolenic acid, once a week to maintain ROS DHA at
near
normal levels. Diets and linseed oil supplementation were continued for 7 to 12
weeks. To
replenish DHA in their ROS, some 10-week-old rats on the deficient diet were
given
linseed oil three times a week for up to 3 additional weeks. Groups of animals
were killed
at various times for ROS fatty acid determinations or were exposed to intense
green light
using intermittent or hyperthermic light treatments. The extent of retinal light
damage
was determined biochemically by rhodopsin or photoreceptor cell DNA measurements
2
weeks after exposure and morphologically by light and electron microscopy at
various
times after light treatment. RESULTS: Rats maintained for 7 to 12 weeks on the
linolenic
acid-deficient diet had significantly lower levels of DHA and significantly
higher levels of
n-6 docosapentaenoic acid (22:5n-6) in their ROS than deficient-diet animals
supplemented once a week with linseed oil or those fed the nonpurified control
diet. As
determined by rhodopsin levels and photoreceptor cell DNA measurements,
deficient diet
rats exhibited protection against retinal damage from either intermittent or
hyperthermic
light exposure. However, the unsaturated fatty acid content of ROS from all
three dietary
groups was the same and greater than 60 mol%. In 10 week-old deficient-diet rats
given
linseed oil three times a week, ROS DHA was unchanged for the first 10 days,
whereas
22:5n-6 levels declined by 50%. After 3 weeks of treatment with linseed oil, ROS
DHA and
22:5n-6 were nearly the same as in rats supplemented with linseed oil from
weaning. The
time course of susceptibility to retinal light damage, however, was different.
Hyperthermic
light damage in rats given linseed oil for only 2 days was the same as for rats
always fed
the deficient diet. Six days after the start of linseed oil treatment, retinal
light damage was
the same as in rats given the linseed oil supplement from weaning. Morphologic
alterations in ROS of linseed oil-supplemented rats immediately after
intermittent light
exposure were more extensive than in either the deficient-diet animals or those
fed the
control diet. The deficient-diet rats also exhibited better preservation of
photoreceptor
cell nuclei and structure 2 weeks after exposure. CONCLUSIONS: Rats fed a diet
deficient
in the linolenic acid precursor of DHA are protected against experimental
retinal light
damage. The relationship between retinal light damage and ROS lipids does not
depend on
the total unsaturated fatty acid content of ROS; the damage appears to be
related to the
relative levels of DHA and 22:5n-6.
Mech Ageing Dev 2000 Jan 10;112(3):169-83. Double bond content of phospholipids
and
lipid peroxidation negatively correlate with maximum longevity in the heart of
mammals.
Pamplona R, Portero-Otin M, Ruiz C, Gredilla R, Herrero A, Barja G.
Prostaglandins Leukot Essent Fatty Acids 2001 Feb;64(2):75-80. Comparative
studies on
lipid peroxidation of microsomes and mitochondria obtained from different rat
tissues:
effect of retinyl palmitate. Piergiacomi VA, Palacios A, Catala A.
Prog Clin Biol Res 1989;312:229-49. Inhibitors of the arachidonic acid cascade
in the
management of ocular inflammation. Srinivasan BD, Kulkarni PS.
J Nutr 2000 Dec;130(12):3028-33. Polyunsaturated (n-3) fatty acids susceptible
to
peroxidation are increased in plasma and tissue lipids of rats fed
docosahexaenoic acid-
containing oils. Song JH, Fujimoto K, Miyazawa T. "Thus, high incorporation of
(n-3) fatty
acids (mainly DHA) into plasma and tissue lipids due to DHA-containing oil
ingestion may
undesirably affect tissues by enhancing susceptibility of membranes to lipid
peroxidation
and by disrupting the antioxidant system."
J Hypertens Suppl 1985 Dec;3 Suppl 3:S107-9. Seasonal variation in the
development of
stress-induced systolic hypertension in the rat. Weinstock M, Blotnick S, Segal
M.
"Seasonal variation in blood pressure in human hypertensives prompted us to
investigate
whether such a phenomenon also occurs in rats made hypertensive by environmental
stress." "Systolic pressure increased by 14-25 mmHg after 6-8 weeks of stress
from
October to January. Artificial environmental light for 15 h prevented
development of
hypertension by stress, which could also be reversed by acute administration of
propranolol." "Hypertensive rats had significantly greater relative heart and
adrenal
weights. This phenomenon can be explained by amplification of sympathetic
pressor
activity by stress hormones, adrenaline, corticosterone and prolactin, under the
influence
of melatonin."
J Neurochem 1986 Oct;47(4):1181-9. Effects of arachidonic acid on glutamate and
gamma-aminobutyric acid uptake in primary cultures of rat cerebral cortical
astrocytes
and neurons. Yu AC, Chan PH, Fishman RA.
Comp Biochem Physiol A. 1989;94(2):273-6.
The effects of essential fatty acid deficiency on brown adipose tissue activity
in rats
maintained at thermal neutrality.
Yazbeck J, Goubern M, Senault C, Chapey MF, Portet R. Laboratoire d'Adaptation
Energetique a l'Environnement, College de France, Paris. 1. The consequences of
essential
fatty acid (EFA) deficiency on the resting metabolism, food efficiency and brown
adipose
tissue (BAT) thermogenic activity were examined in rats maintained at thermal
neutrality
(28 C). 2. Weanling maleLong-Evans rats were fed a hypolipidic semi-purified
diet (control
diet: 2% sunflower oil; EFA-deficient diet: 2% hydrogenated coconut oil) for 9
weeks. 3.
They were kept at 28 C
for the last 5 weeks. Compared to controls, in EFA-deficient rats the growth
shortfall
reached 21% at killing. 4. As food intake was the same in EFA-deficient and
control rats,
food efficiency was thus decreased by 40%. 5. Resting metabolism expressed per
surface
unit was 15% increased. 6. Non-renal water loss was increased by 88%. 7. BAT
weight was
28% decreased but total and mitochondrial proteins were not modified. 8. Heat
production
capacity, tested by GDP binding per BAT was 69% increased in BAT of deficient
rats. 9. The
stimulation of BAT was established by two other tests: GDP inhibition of
mitochondrial O2
consumption and swelling of mitochondria. 10. It is suggested that the observed
enhancement of resting metabolism in EFA-deficient rats is, in part, due to an
activation of
heat production in BAT.
Eur J Biochem. 1983 Dec 1;137(1-2):113-8. NADH oxidation in submitochondrial
particles
protects respiratory chain activity against damage by adriamycin-Fe3+. Demant
EJ.
Oxidative decomposition of polyunsaturated fatty acid moieties of membrane lipid
in pig
heart submitochondrial particles, as initiated by ferric ion complexes of the
antineoplastic
drug adriamycin and concomitant inactivation of oxidase activities, is
counteracted by
EDTA, low oxygen pressure, a phenolic antioxidant and NADH oxidation through the
respiratory chain but not by scavengers of reactive oxygen species. Protection
by NADH is
strengthened by removal of cytochrome c from the
submitochondrial particles and by antimycin A but abolished by rotenone.
Inhibition of
cytochrome c oxidase activity by the adriamycin-Fe3+ complex is reversible and
activity is
recovered upon cholate solubilization of the particles. ADP inhibits binding of
the complex
to the submitochondrial particles and protects both cytochrome c oxidase
activity and
membrane lipid. The results are discussed in relation to the possible role of
mitochondrial
function in protection against free-radical-mediated effects of adriamycin.
Free Radic Biol Med. 1999 Jul;27(1-2):51-9. Arachidonic acid interaction with
the
mitochondrial electron transport chain
promotes reactive oxygen species generation. Cocco T, Di Paola M, Papa S,
Lorusso M.
Institute of Medical Biochemistry and Chemistry, University of Bari, Italy. A
study has been
carried out on the interaction of arachidonic acid and other long chain free
fatty acids with
bovine heart mitochondria. It is shown that arachidonic acid causes an
uncoupling effect
under state 4 respiration of intact mitochondria as well as a marked inhibition
of
uncoupled respiration. While, under our conditions, the uncoupling effect is
independent
of the fatty acid species considered, the inhibition is stronger for unsaturated
acids.
Experiments carried out with mitochondrial particles indicated that the
arachidonic acid
dependent decrease of the respiratory activity is caused by a selective
inhibition of
Complex I and III. It is also shown that arachidonic acid causes a remarkable
increase of
hydrogen peroxide production when added to mitochondria respiring with either
pyruvate
+malate or succinate as substrate. The production of reactive oxygen species
(ROS) at the
coupling site II was almost double than that at site I. The results obtained are
discussed
with regard to the impairment of the mitochondrial respiratory activity as
occurring during
the heart ischemia/reperfusion process.
Arch Biochem Biophys. 1991 Aug 15;289(1):33-8. A possible mechanism of
mitochondrial
dysfunction during cerebral ischemia: inhibition of mitochondrial respiration
activity by
arachidonic acid. Takeuchi Y, Morii H, Tamura M, Hayaishi O, Watanabe Y.
Department of
Neuroscience, Osaka Bioscience Institute, Japan. The dramatic increase in the
arachidonic
acid (AA) level in the brain is a well-known molecular event during cerebral
ischemia. As
mitochondria are known to be one possible site of the cell damage, the effects
of AA on
the respiratory activity of rat brain mitochondria were investigated in vitro
using an
oxygen electrode. In NAD-linked respiration, respiratory control ratio was
decreased
significantly by AA, with an IC50 of 6.0 microM. AA had the dual effect on
mitochondrial
respiration, a decrease in state 3 and uncoupled state and an increase in state
4 (i.e.,
uncoupling) as reported by Hillered and Chan (J. Neurosci. Res. 19, 94-100,
1988).
Furthermore, we found that other unsaturated long-chain free fatty acids
(C18:1-C18:3,
C20:1-C20:5) also showed such a dual effect. Cyclooxygenase metabolites of AA
such as
prostaglandins (D2, E2, F2 alpha, E1) and thromboxane B2, and lipoxygenase
metabolites
such as leukotrienes (D4, B4) and 5- or 12-hydroperoxyeicosatetraenoic acid had
no
significant effect. The inhibition of the uncoupled state by AA was more marked
in NAD-
linked than that in FAD-linked respiration, while the degree of uncoupling by AA
were the
same in both respirations. In spectrophotometrical measurement, the reduction of
cytochromes and flavo-protein was markedly inhibited by AA in NAD-linked
respiration,
but not in the FAD-linked one. In addition, the activity of cytochrome c oxidase
was
scarcely inhibited by AA. These data suggest that AA itself, not its
metabolites, may inhibit
mitochondrial ATP production during brain ischemia and that AA may act on the
site(s)
closely related to NAD-linked respiration, but not the FAD-linked one, in
addition to its
uncoupling effect.
Atherosclerosis. 2001 Mar;155(1):9-18. Enhanced level of n-3 fatty acid in
membrane
phospholipids induces lipid peroxidation in rats fed dietary docosahexaenoic
acid oil.
Song JH, Miyazawa T. Department of Applied Biological Chemistry, Faculty of
Agriculture,
Tohoku University, 981-8555, Sendai, Japan. The effect of dietary
docosahexaenoic acid
(DHA, 22:6n-3) oil with different lipid types on lipid peroxidation was studied
in rats. Each
group of male Sprague-Dawley rats was pair fed 15% (w/w) of either
DHA-triglycerides
(DHA-TG), DHA-ethyl esters (DHA-EE) or DHA-phospholipids (DHA-PL) for up to 3
weeks.
The palm oil (supplemented with 20% soybean oil) diet without DHA was fed as the
control. Dietary DHA oils lowered plasma triglyceride concentrations in rats fed
DHA-TG
(by 30%), DHA-EE (by 45%) and DHA-PL (by 27%), compared to control. The
incorporation
of dietary DHA into plasma and liver phospholipids was more pronounced in the
DHA-TG
and DHA-EE group than in the DHA-PL group. However, DHA oil intake negatively
influenced lipid peroxidation in both plasma and liver. Phospholipid
peroxidation in
plasma and liver was significantly higher than control in rats fed DHA-TG or
DHA-EE, but
not DHA-PL. These results are consistent with increased thiobarbituric acid
reactive
substances (TBARS) and decreased alpha-tocopherol levels in plasma and liver. In
addition,
liver microsomes from rats of each group were exposed to a mixture of chelated
iron (Fe(3
+)/ADP) and NADPH to determine the rate of peroxidative damage. During NADPH-
dependent peroxidation of microsomes, the accumulation of phospholipid
hydroperoxides, as well as TBARS, were elevated and alpha-tocopherol levels were
significantly exhausted in DHA-TG and DHA-EE groups. During microsomal lipid
peroxidation, there was a greater loss of n-3 fatty acids (mainly DHA) than of
n-6 fatty
acids, including arachidonic acid (20:4n-6). These results indicate that
polyunsaturation of
n-3 fatty acids is the most important target for lipid peroxidation. This
suggests that the
ingestion of large amounts of DHA oil enhances lipid peroxidation in the target
membranes where greater amounts of n-3 fatty acids are incorporated, thereby
increasing
the peroxidizability and possibly accelerating the atherosclerotic process.
Atherosclerosis. 1996 Apr 5;121(2):275-83.
Effect of dietary fish oil supplementation on peroxidation of serum lipids in
patients with
non-insulin dependent diabetes mellitus.
McGrath LT, Brennan GM, Donnelly JP, Johnston GD, Hayes JR, McVeigh GE.
Department of
Therapeutics and Pharmacology, The Queen's University of Belfast, Belfast, UK.
Lipid
peroxidation may be important inthe development of cardiovascular disease, a
common
cause of mortality and morbidity in non-insulin dependent diabetes mellitus
(NIDDM). We
assessed the degree of lipid peroxidation by measuring plasma malondialdehyde,
as
thiobarbituric acid reacting substances (TBARS), in 23 non-insulin diabetic
patients.
Plasma levels of standardised alpha-tocopherol (vitamin E), lipid content of
whole plasma
and lipoprotein fractions, glycosylated haemoglobin, glycosylated low density
lipoprotein
(LDL) and fasting blood glucose were also measured. On completion of the
baseline
studies patients randomly received either fish oil or matching olive oil
capsules in a double
blind crossover fashion for 6 weeks followed by a 6 week washout period and a
final 6
week treatment phase. Studies, identical to the initial baseline studies, were
performed at
the end of the of the active treatment periods at 6 and 18 weeks. Treatment with
olive oil
did not change levels of TBARS, vitamin E or indices of glycaemic control
compared with
baseline. Total cholesterol and triglyceride (TG) content of plasma and
lipoprotein
fractions were not significantly altered. Treatment with fish oil resulted in
elevation of
TBARS (P < 0.001) and reduction of vitamin E (P < 0.01) compared with baseline
and olive
oil treatment. Plasma cholesterol was unchanged. A reduction in plasma TG
compared with
baseline occurred but failed to reach significance (P =0.07). Changes in apo B
containing
lipoproteins induced by fish oil failed to reach significance. No significant
changes were
observed in concentration or composition of high density lipoprotein (HDL). Fish
oil
treatment showed no change in glycaemic control as assessed by glycosylated
haemoglobin and LDL although a rise in fasting blood glucose just failed to
reach
significance (P = 0.06). Lipid peroxidation in NIDDM can be exacerbated by
dietary fish oil.
This potentially adverse reaction may limit the therapeutic use of fish oils in
such patients.
Clinical Trial
Randomized Controlled Trial
Raymond Peat, Ph.D.

The Rosacea Research & Development Institute [RRDi] is pleased
to announce that Michelle Pelle, M.D., has been appointed as a member of the
Medical Advisory Committee for the RRDi.
Dr. Pelle is a researcher and assistant clinical professor at UCSD, SOM,
Department of Dermatology. Dr. Pelle uniquely specializes in the care of severe
skin diseases. For more information about her background go to this url
http://www.MedDerm.net/curriculum.html
Dr. Pelle has written several research papers on rosacea. For a list
of her PubMed articles go to this url
http://tinyurl.com/yw7l38
The RRDi is pleased that Dr. Pelle has agreed to volunteer
her time to assist the RRDi. She is joining 20 other professionals on
the RRDi Medical Advisory Committee [MAC] who have graciously volunteered
their time to assist in answering questions. You may review the list
at this url
http://irosacea.org/mac.php
The RRDi is a 501 (c) (3) approved non profit organization that has
been built entirely by volunteer rosaceans. The MAC members are
all professionals who are volunteering their time to listen to the
concerns of rosacea sufferers in a safe private forum for corporate
members. Corporate members are required to give their identity and
mailing address before being approved to be able to access our private
forum. The RRDi has a strict privacy policy and your privacy is safeguarded.
The RRDi has professional grant writers who have volunteered to write
grants on rosacea research who will be later compensated 10% of whatever
money brought to the RRDi for this purpose. Amateur grant writers are
encouraged to volunteer as well and learn from the professionals how to
write grants in the private forum section for grant writers. If you wish to
learn more about this join the RRDi and volunteer as a grant writer.
The board of directors of the RRDi are all suffering from rosacea and
this should encourage rosaceans that the RRDi will make decisions
regarding the spending of donations on rosacea research rather than the majority
of the funds being used for other purposes. You may review who is
volunteering on the board at this url
http://www.irosacea.org/board.php
Volunteering is the spirit behind the success of the RRDi and we encourage
you to bring what talents you have and any energy or time you would like to
give to find a cure for rosacea. If you would like to join please do so at this
url
http://members.irosacea.org/index.php?act=Reg&CODE=00
Finding the Cure - RRDi
Brady Barrows
Director RRDi
http://www.irosacea.org

I have been on a campaign to understand why demodicosis
isn't listed as a subtype or variant of rosacea. Try to ask your
physician that question. Many physicians don't even know
that there are subtypes of rosacea since this is a relatively
new concept for physicians and a dermatologist who isn't
keeping up with rosacea and concentrating on other things
may have missed the new subtype classifications.
Since the RRDi MAC is available to ask questions, though on
a limited basis (each professional has agreed to answer questions
for 15 minutes a month on a volunteer basis and only if they
have the time and are not busy), I have patiently been waiting
for the results of my question. Here are the results so far:
Demodicosis apparently is a disease all on its own, which is
called a 'disease sui generis.' However, Dr. Plewig has explained
that "demodex mites heavily colonize pre-existing rosacea and
thus lead to demodectic rosacea ( rosaceiform dermatosis)."
Thus we have a new term I have never seen before, demodectic
rosacea or rosaceiform dermatosis. I am very happy that at the
very least we have a proper name for it. One physician in 1963
called it 'rosacea-like demodicidosis.' That is a mouth full. So
I really like this new term Demodectic Rosacea. Short, and to the
point. Now this opens up some more questions, like:
Since the demodex mites heavily colonize pre-existing rosacea,
could this be a chicken or egg problem? Is the demodex mites
causing the rosacea since demodex pre-exists the pre-existing
rosacea? Demodex mites are on everyone's face, regardless whether
one has rosacea or not. And since David Pascoe has so kindly
pointed out a new paper from Walter Reed that the "effects of antibiotics
in rosacea [might] be caused by their actions on intracellular bacteria of
Demodex rather than to a postulated anti-inflammatory mechanism" by
doctors Burroughs and Maggio (gotta get these docs on the MAC) and
the new one by Dr. Dr. Kavanagh that says that "this indicates that the Bacillus
bacteria found in the Demodex mite produce an antigen that could be
responsible for the tissue inflammation associated with papulopustular rosacea,"
now having a new term, demodectic rosacea, is appropriate to use.
You can read more about this at this url
http://members.irosacea.org/index.php?showtopic=121
I still haven't figured out whether demodectic rosacea is a variant but I
am patiently waiting for more answers. The professionals in the MAC
are truly amazing to reply to such answers since it no doubts frustrates
them to answer such questions as it does me since rosacea is so complicated
and confusing. Hope springs eternal.
Brady

I posted a similar post on r-s but thought it worthy of posting here as well.
The question was whether one can get demodex mites from their pets?
The demodex on pets that cause mange are species specific and not
demodex folliculorum or brevis, there is an interesting anecdotal
report from Nadia about demodex and pets with a lot of links at this url
http://tinyurl.com/2zse37
T.J. Dunn, DVM, says, in discussing whether demodex mites can be transferred
from a pet to a human:
"...Human demodex cases do occur but transmission from the dog to a human
is quite rare. Nevertheless, human cases of demodex do happen where
transmission from a family pet to a human occurs....
The mites reside and feed in the hair follicle and oil glands of the skin. Also
called Mange, which is a general term used to describe any kind of mite
infestation,..."
The above article supplies photos of a woman with a dermal infestation of
demodex on her face and it looks very much like rosacea. Check it out
http://www.thepetcenter.com/exa/dem.html
Another report says:
"Butler, a veterinary medical entomologist who has studied mites on dogs, said
people probably react to large numbers of mites in the same way as our canine
friends.
"Based on my experience with dogs, particularly young animals whose hormone
and immune systems are not fully developed, you probably get similar results on
people," he said. "Populations can explode on dogs, causing mange-like symptoms.
"The link between mites and hair loss and other skin conditions is not
conclusive, but we do know it's a major problem for dogs," Butler said.
"If you have high levels of hormones, you're going to have high levels of
mite reproduction because these anthropods obtain their steroids from the host."
Butler said Demodex poses the biggest threat to people under stress or those
with cancer or other conditions such as HIV/AIDS that suppress the immune
system. Mite colonies can spread unchecked because patients cannot produce the
antibodies needed to control the parasites." source
http://pestalert.ifas.ufl.edu/acne.htm
Dr. Plewig says that "demodex mites heavily colonize pre-existing rosacea and
thus lead to demodectic rosacea ( rosaceiform dermatosis)."
source
If this is how it works, I would wonder if it would be wise for a rosacean to
cuddle up to a pet with any type of demodex mites? I know what I would do,
but I also know how some rosaceans feel about their pets. Some feel that
being close to their pet is worth even the chance of getting a demodex
infection that turns in to Demodectic Rosacea. See this url
http://www.rosaceans.com/html/demodex.html
Another report in 2001 says, "It seems likely that Demodex infestation does not
manifest unless local or systemic immune function is altered, leading to the
proliferation of the organism and subsequent disease."
source
One clinical report says that "Oral metronidazole seems to work in the
management
of this chronic mite infestation" source
And last but not least, Ivermectin is usually the drug of choice along with
topical Permethrin and oral metronidazole if you are treated by a physician.
However, the ZZ cream will work fine to
http://www.rosaceans.com/html/z2.html
Brady
group owner

or French Maritime Pine Bark extract. Has anyone heard of this? I
read that it has the ability to block glucose absorption and if so
where does the glucose go? I am curious about this because I was
given stromectol and permethrine cream (sorry about the spelling).
The very next day I had almost total clearing of the face. The
stromectol seems to have the ability of blocking glucose uptake. The
research I did on this med lead me to the pycnogenol. Just wondering
if the pycnogenol could be helpful for rosacea and if there would be
any long term side effects from it? I was given the stromectol and
permethrine cream from a derm for rosacea. I had had an itch or
tickle sensation in my abdomen, below the belly button area for
about 5 years. This was internal, no matter how much I scratched the
outside, there was no releif. It did come and go but the past year
occured off and on all day. Strange as it is, this sensation
completely stopped about within an hour of taking the stromectol 3
weeks ago. It has not occured since. I also had a jumpiness in my
heart, like a thudding several times a day for the past 5 years or
so. Both of these symtoms came on slow and continually increased in
occurance over time. This second symptom has also completey stopped.
Has not happened once in the past 3 weeks. I have been to dozens of
different doctors in the past 5 yrs, also when my rosacea started,
had an upper GI-no findings, wore a heart monitor-inconclusive
results, infectious disease Dr. 10 months ago who said I was
stressed out, depressed and it was all in my head (she never took
one test of any kind just deduced this after talking with me for
about 20 min), etc, etc. Anyway, my energy is back and I feel
tremendously better. Still have a little rosacea but with diet it
seems to get under some control. Sorry I haven't been on for a
while, all these kids keep me so busy. Thanks, Jen

Someone pointed out at the Rosacea Forum that Corposcindosis is a
disease that may occur after ETS.
If you click on the abstract you will find these sentences:
"The typical etiology (cause) of CS is surgical sympathectomy in the upper
thoracic region
(ETS surgery), but could also manifest as a result of injury or disease of the
thoracic
sympathetic nerve ganglia."
And this one:
"Changes to systemic function may include: poor thermoregulation (including loss
of
selective brain cooling), diminished exercise capacity, and calcification of
arteries. Primary
psychiatric effects may include: diminished experience of strong emotions.
Secondary
psychiatric effects may include: anger, depression, suicide and suicidal
thoughts.
Corposcindosis is a disease in every sense of the word. Corposcindosis is
definable,
predictable, measurable, photographable, disabling, preventable, and, for now,
incurable.
Subjectively, patients may consider corposcindosis to be "life ruining",
"hateful" and
"disturbing"."
The source of the above two items can be found at this url
http://editthis.info/corposcindosis/Main_Page
My editorial on ETS can be found at this url
http://www.rosaceans.com/html/ets.html
If you haven't heard of ETS for rosacea then you should read the above
editorial.
Brady
group owner

I'm not aware of Pycnogenol helping with glucose but I am aware that is a
wonderful antioxidant and can have anti allergy effects, which could be a
possible contributor to rosacea. Also it helps to strengthen blood vessels.
Certainly can't hurt to give it a try. I've added it to my supplement regime.
I am really curious about the treatments you have tried for your rosacea. Are
these topicals?
Noreen

I have an editorial on the NRS which has been published for some time now and
you can read it at the following url
http://www.rosaceans.com/html/nrs.html
I have added the following quote from the 2005 Form 990, Part V-A, - Line 75C:
"Three of the seven directors of the National Rosacea Society (NRS), Samuel B.
Huff, Datha J. Olney and Mary F. Erhard, are employed by Glendale Communications
Group (Glendale). Glendale provides the personnel and infrastructure, and
carries certain outside expenses, needed to support and implement the program
services and administration of the NRS, and also provides services to other
clients unrelated to the NRS. The postiions of these NRS directors with Glendale
and their total salaries from Glendale in 2005 are as follows:
Name, Glendale Position, 2005 Salary
Samuel B. Huff, President, $202,948
Datha J Olney, Technical Support, 8,221
Mary F. Erhard, Medical Editor, 42,587
Because of their relationship, NRS directors associated with Glendale abstain
from all board of director votes affecting Glendale, and only the NRS directors
not associated with Glendale (The "Independent NRS Directors") review and
approve activities and budgets affecting Glendale. Each year, the Independent
NRS Directors review the continuation of the NRS's relationship with Glendale,
and must approve retention of Glendale by the NRS annually. In additin, at least
one of the Independent NRS Directors reviews monthly invoices from Glendale to
the NRS. Glendale's fees to the NRS are determined on the same basis as for
other Glendale Clients, and the Independent NRS Directors are provided with
competitive cost estimates for specific projects undertaken by Glendale on
behalf of the NRS." [Source Form 990 - Year 2005]
Most rosaceans could care less how the NRS runs its organization. Most rosaceans
could care less that the NRS received over the past eight years in donations a
total of $6,201,400 and spent a total of $561,132 on rosacea research. That
means that about 9% of total donations was spent on research. That means that of
every dollar donated to the NRS about nine cents is spent on research. What
happened to the rest of the donations? Over the last eight years $3,762,050 of
the total funds of the NRS have been spent on one independent contractor,
Glendale Communcations Group, Inc., of Barrington, Illoinois which is owned by
Sam Huff. Sam Huff is also the President of the NRS. A few rosaceans have
thought that something should be done about it. Some think that all one has to
do is donate to the NRS and specify that the donation go to rosacea research.
However, a few rosaceans have volunteered to make a non profit that will spend
90% of the donated funds to actual rosacea research and only use 10% to run the
organization. If you want to help, go to
http://www.irosacea.org
Volunteer and help find a cure for rosacea.
Brady Barrows
group owner

Drew,
The problem with demodex is that there is a chicken or the egg syndrome
going on. Demodex mites are on EVERYONE, non rosaceans and rosaceans.
The question is whether the demodex are causing the problem or if pre-
existing rosacea is aggravated by the demodex? No one knows. I quote
Dr. Plewig on this this here
"Concerning your questiones, demodicosis can be a disease by itself and
thus being independent of rosacea. Or demodex mites heavily colonize
pre-existing rosacea and thus lead to demodectic rosacea (rosaceiform
dermatosis).
This is a rather complicated issue. Rosacea is usually diagnosed by inspection
the eye.
Laboratory tests are rarely needed, for instance in gram-negative rosacea, where
one
needs bacteriology. The same is true for demodectic rosacea, where one has to
demonstrate the mites in great numbers. " source
http://members.irosacea.org/index.php?showtopic=121
There is at least one report that physicians have used Ivermectin to treat
rosacea

Hello Brady,
It's been a long time and I hope you're doing well. I saw a couple
of your posts regarding rosacea issues and hoped to promote further
discussion.
One interesting thing regarding inflammation pathways is that if one
goes back to the origin, i.e. before arachidonic acid, leukotrienes,
and the like, there is something fundamentally wrong with our skin:
it percieves insult to what others might consider innocuous stimuli.
This then initiates the entire inflammatory process.
Now, is it possible that demodex infestation or an allergy to demodex
could be this fundamental flaw? Could demodex weaken the skin's
ability to handle what ultimately become our triggers?
Consider too why isotretinoin is supposed to work in some people. It
dries up sebaceous glands, the place where demodex takes refuge and
sustains itself. Could this be the key?
I tried ivermectin a while ago but this did not seem to help.
demodex solutions says as much but does not specify why. Any ideas?
As a consequence of this experiment i, perhaps erroneously, ruled out
demodex as a possible cause for my rosacea.
i also tried zz cream in the past but apparently not long enough.
Now, given the restored interest, I'm trying it again.
Please note that my face is dried. Will i get past this stage or
will i damage my skin further? I ask because you seem to be aware of
the zz cream's effects.
Another interesting point you mention is the psychological aspect of
rosacea. The question is: does undue stress cause rosacea or does
rosacea cause undue stress?
I believe you are familiar with J prarie's book. According to the
author, rosacea is frequently accompanied by:
depression; social phobia; persecution anxiety; a muted psychotic
rage.
While that last tidbit is a somewhat damning indictment of rosacea
sufferers, I would like to believe it is not representative of all of
us. Just the same, having witnessed the hostility on some of the
other boards, who knows?
Getting back to the main point, it's difficult to say which comes
first (rosacea or psychological problems)although I must confess that
i grew up in an unhappy home with many issues. Were this not enough,
I'm also a recovering roman catholic and you know how they are with
regard to anything corporeal. I wonder if any of these factors
hastened my rosacea onset. My skin grew bad just around puberty.
Hmmmmm. Suffice it to say, i had some pretty bad caregivers.
Anyhow, i hope you will give thought to my questions. i am also
trying red light therapy though it is too early to say whether it is
helping. i have only been on it for four and a half weeks.
I'm trying to control my swelling which seems to be inspired by my
extreme anxiety associated with mirrors. You see, my self image is
held in the mirror and it is not a pretty one. This fear seems to
spur the reaction and i have no doubt it is born of the events of my
youth. Interestingly, this appears to be yet another mind-body
correlation. Perhaps there is no escaping the connection.
I've been concentrating on the physical processes surrounding this
disease for the longest time and am just starting to consider the
psychological elements. Any help from you would be much appreciated.
Best wishes,
Drew

I've not tried any Neem before. I noticed that the cream is
recommended as a daily moisturizer. How does this compare to using
jojoba oil? I also noticed that there is a bar soap of Neem. Would
this be a preference over using something like cetaphil? I'd dearly
like to see my skin move away from being so dry. Cetaphil's
moisturizer is ok under makeup during the day. I've not attempted
using jojoba oil under makeup as I don't really have the time to wait
for it to soak into my skin, but I do protect my face with it at night.

Do NOT use bar soap, it is way too alkaline for the skin.
You should give Jojoba oil a try, it is much better for your skin and you
actually might like it better than Cetaphil.
Your cleanser is key, what are you using to cleanse?
So many rosacea sufferers use nothing or the wrong things on their skin.
Noreen

Dear ru2bu--
I have asked many questions about the acvwm, as well, but I was very happy
to find in my pantry a bottle of Bragg Apple Cider Vinegar with the Mother,
something I apparently purchased when acvwm was a subject on the boards some
time ago. It specifically decribes drinking several times per day the solution
described below (1 tsp acvwm in 1 cup water) as a healthy pick-me-up. I
tried it yesterday, expecting the drink to be yukky, and found it was not half
bad.
Hope I get the same results that others are describing, but it's only been
two days at this point. We shall see.
In a message dated 3/14/2007 5:42:47 P.M. Eastern Standard Time,
ru2bu_ibme@... writes:

I wear Physicain's Formula and have no problems. ALL of the others I have tried
have caused more redness and more blemishes. I wear nothing else. I did find a
lady who sells PF for $1.25 new in package shipped to you from FL. If you are
interrested let me know.
Tonya
Mechelle <txcactusblossom@...
During the past week, I have been trying a few different mineral
makeups. I tried Pur Minerals, but took it back to the store. within
an hour of wearing it, I felt tight and dry around my mouth. I was
wearing a cetaphil moisturizer and noxadem underneath. I did come
across information that bismuth oxychloride can cause dryness and
itching in sensitive skin. Bismuth oxychloride is in Pur Minerals 4
in 1. Now, I'm trying a sample from www.everydayminerals.com. Their
prices are very affordable. I am getting good coverage on the
redness, but now am feeling some tingling/burning on the apples of
my cheeks and in the smile lines around my mouth. It's not bad
enough that I feel an urge to go wash it off immediately and it's
not always consistent. Again, I do have a moisturizer underneath,
but used MSM lotion this morning instead of the usual
cetaphil/noxadem. I am wondering if perhaps I am not having a
problem with mica or if something else is going on. I did notice
that after i washed off the Pur Minerals, my forehead had blotches
of red. I did not see that with the Everyday Minerals. I also had
some other sort of blemish come up while wearing the Pur Minerals.
I'm beginning to think that maybe I should just go back to wearing
the chemical laden Physician's formula since I've had these varying
reactions to crushed minerals or maybe find another line to try
(that's getting rather pricy now). Any suggestions or information?

Hello everyone, I've been struggling with Rosacea on my own now for
about 15 years. I've had quite a bit of IPL which has really made a
difference, but I'm now trying to find a treatment for the
pimples/pustules which come and go.
I've read on this website about vitamin K, and I'm interested to try
it. I did a google search and there is a company called
www.rosaceacare.com who sell vitamin K cream. Has anyone used this
brand, if not, which brands have you been using.
I'm so warey of impulse buying on the internet, because there are so
many scams out there and it's so easy to waste money. I even wondered
if this group was a cunning way of promoting goods!! So cynical!
Anyway if anyone has tried rosacea care products or could recommend
somewhere to buy vitamin K cream, that would be helpful.
Many thanks, Linda

I have found an excellent method for me to exfolliate, it actually
works better than anything I've ever used, cheap and at your home
already. Everything else I've always used either roughed me up more
and irritated me, or just did not affect my dry flakeness. If anyone
is in need or interested, I'll gladly post this wonderful method. It's
been wonderful for me anyway.

I have been criticized since 1999 that the Rosacea Diet is not a healthy diet
but more studies have shown that eating low carb is not as bad as everyone
thinks.
Here is a quote from a recent study done at Harvard:
"A new Harvard School of Public Health (HSPH) studythe first to examine the
long-term effects of low carbohydrate dietshas found there is no association
between such diets and an increased risk of developing coronary heart disease
(CHD).
The study, which appeared in the Nov. 9 issue of The New England Journal of
Medicine, relied on data collected from HSPH's Nurses' Health Study, a sweeping
project which collected data from over 120,000 women starting in 1976.
HSPH researchers also found that there was an association between a lowered risk
of heart disease and low-carb diets that were high in vegetable sources of
fat and protein.
"We are not recommending a low-carb diet over a low-fat diet," said
Thomas L. Halton, one of the authors of the study.
"The truth of the matter is that neither [is] ideal. Both have good points and
bad points."
According to Halton, carbohydrate and fat sources have a greater impact on the
risk of CHD than the quantity of carbohydrates and fat consumed.
"You can take the best of both diets and eliminate the negatives by focusing on
vegetable sources of fat and protein and choosing lower glycemic sources of
carbohydrates," said Halton, a former HSPH doctoral student.
Non-dietary factors such as levels of cholesterol and blood pressure, as well as
diabetes and exercise, did not appear to impact the relationship between
low carb diets and CHD risk.
"We controlled for [those factors] in our analyses so we can say the association
between low carb diet and risk of CHD was independent of other risk factors for
CHD," Halton said.
source
http://www.thecrimson.com/article.aspx?ref=515865

Please post your method. I am most interested.
Thank you.

I wear Jane Iredale, which is a line that estheticians and physicians sell, I
have no problem with this one. I also do not seem to have a problem with
Bismuth.
You could try visiting an esthetician or going to a medispa that sells better
quality mineral makeup. The mineral makeup sold in CVS, Walmart, Walgreens etc
is not mineral makeup in its pure form, many ingredients added to those products
that can irritate skin.
Some people do have trouble with Mica but I have also know folks that had
problems with titanium and zinc.
If you react, return it. If more people would return cosmetics they react to,
the cosmetic companies might clean up their act.
There are many other wonderful mineral makeups out there, but they are NOT being
sold at the local drugstore. Do you have a Sephora near you?
Noreen

definitely post, please.
Noreen

Mine goes back and forth. I think the drying is from my metrogel but other than
that I have normal skin.
Tonya
ru2bu_ibme <ru2bu_ibme@...
By the way, is your skin extremely dry? Just wondering, since you
don't have a problem with those, I'm not above trying minerals again.

Hi!
I just want to tell you about some info I got regarding the Rosacea
care products. I have never tried the products, but I will order
them soon. A week ago my mother gave me an article from a (norwegian)
magazine. It was about a man and a woman with rosacea, and after
using the Rosacea care line, the symptoms were dramatically reduced.
Now they wanted to let other people hear about the products. They
had a before&after picture, and it was a big difference. I have
tried a vitamin K cream in another brand, but it didnt help me much.
But the Rosacea care line has a combination of different things, not
only vit. K. I would love to hear other sucsess stories! But
something that worked for them, may not work for us. Ive tried ltd
III without very much results, but many others have sucsess with the
disks. IPL made my skin much more red, and I think the woman (she
was not a doctor) burned me/over treated me (I have read many really
good reviews about IPL, but for me it was a sad story). I now go to
a really good doctor who knows what he is doing, and Ive done with
one Versapulse and 3 Vbeam treatments. I always get an ice pack
after the treatment. The last one I had only two weeks ago, so Im
still waiting for the result to show. I guess Im about 50% better
(redness), and hoping that the change is even better in 2-3 weeks.
AM

Mineral makeup is not for everyone. I personally love it.
You may just need to find a regular foundation makeup that works for you.
Regarding the dryness, sometimes people mistake dehydration with dryness.
Drinking lots of water is very important, as well as consuming enough good oils
in your diet.
Finding the right moisturizer can be very tricky but with the help of a good
esthetician you should be able to find something that works for you.
IMO Cetaphil products are not good cleansers or moisturizers.
Many companies will send you samples, perhaps getting some samples will help you
narrow down the product that works for your skin.
Noreen

Hi Brady,
I just have to write. My husband is 42 and has suffered horrifically from
Rosacea for the past few years... I would classify his case as severe. No
releif ever, no letting up... constant Huge pustules, redness, swelling and
face bleeding every morning. When coming out of the shower his face used to be
blood red. Then would settle down to deep red. He even had to wear makeup
every day to go to work. This from what I would consider to be a very
masculine man was very troublesome.
I finally took the leap of faith and ordered him the Z cream. Its been
about 10 days and he must be at least 80% better.! (He hasnt even finished the
first jar) Today he went to work with no makeup! He probably could have
stopped a few days ago... Within just a few days all pustules were gone. no
bleeding... no deep blood red flushing....his skin actually shed off of his
face,
leaving nice brand new skin. His nose was enlarged and his face swollen
from all the lumps and bumps.. he said he could actually look down and see the
bumps on his own face....One day a pustule on his nose burst and it bled and
bled for a couple of hours until he finally got some liquid bandage to seal
it.
.People at work have asked him if he somehow lost weight in his face... his
facial swelling has gone down that much. I never remembered his nose being
so small! We are dancing about now! We are so thrilled. He only has a few
small bumps on his forehead yet and some very minor pinkness to his skin. He
plans to use it for the entire 3 months and keep a jar on hand.. but this
seems to be his answer! We are astonished at how quickly he has noticed
results. In addition he is using the acrid removing face wash but that is
about
it. Again a huge thanks! Any other advice? Will the z cream continue to
keep his rosacea at bay? For him, this has been a miracle... ! Again... thank
you!
Laurie Perez

Just found this interesting bit of information:
"It appears that the addition of an oral antibiotic to a treatment regimen that
includes Nic/Zn
tablets may not be necessary because the combination did not significantly
increase the
percentage of patients responding. Nic/Zn [nicotinamide and zinc] tablets
appear to be an
effective oral therapy for the treatment of acne vulgaris and rosacea when used
alone or with
other topical therapies and should be considered a useful alternative approach
to oral
antibiotics for the treatment of acne vulgaris and rosacea."
source
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16871775&query_hl=1&itool=pu
bmed_DocSum
Brady
group owner

Do most or all rosaceans have something in commen:
Excess amount of vitamin or mineral buildup,
Use of antidepressants or other med that disrupted nerve pathways or
something,
Excess use of alcohol or tabacco,
Large amounts of caffiene intake over time,
Some type of inability to process msm sulfer, (sulfer seems to help
the skin)
Habitually unhealthy eating habits for several consecutive years,
????? It would be interesting to see some commonalities.
Just rambling, thanks for listening. Jen

Hope you had a Happy Thanksgiving! So, what other foods are you eating- meats,
vegetables??? I am glad to hear that things are going well for you. I haven't
tried the discs yet- I ordered the jojoba oil online, should have just bought
it in the store, but they didn't have it in the nearby health food store and we
don't have a GNC near us, so it was easy just to order it. My skin is dry now
though, because I am just using the cetaphil soap and stopped using the
moisturizer I was using- just waiting for the jojoba oil to come in the mail.
Please keep me posted! Maureen
craig kudel <bklynknight1023@...
Happy thanksgiving, Things seem to be going good with
the jojoba oil and disc i also am continuing with
watching what i eat. I am eating a lot of
blueberrries and have limited my sugar in take. I have
been eating a salad with lunch and dinner i ate a big
lunch at my companys thanksgiving lunch and had only a
minor flair up probably from the cake and or chicken